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    Abstract

    Crystal-storing histiocytosis is a rare condition that is histologically characterized by intracellular cytoplasmic crystalline inclusions. It usually presents monoclonal immunoglobulins that deposit within histiocytes, which accumulate and affect different organs of the human body and are commonly associated with lymphoproliferative conditions, especially those with plasmacytic differentiation. The prognosis of this condition is variable and related to the underlying clinical disease. In this review article, we aim to describe and discuss the clinical and pathological characteristics of crystal-storing histiocytosis based on the available literature and to provide a thorough differential diagnosis.

    Keywords: crystal storing histiocytosis, multiple myeloma, lymphoma, histiocytosis, eosinophilic, inclusions, macrophages

    1. Introduction

    Crystal-storing histiocytosis is a rare condition that was firstly described by Glaus in 1917 [1]. It is histologically characterized b

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      Year : 2019Month : October-December Volume : 8 Issue : 4Page : PO17 - PO21

      A Two Year Retrospective Study of Direct Immunofluorescence in Autoimmune Vesiculobullous Lesions with Clinical Correlation

      Sarojini Raman, Chandra Sekhar Sirka
      1. Associate Professor, Department of Pathology, KIMS, Bhubaneswar, Odisha, India. 2. Additional Professor, Department of Dermatology and Venereology, AIIMS, Bhubaneswar, Odisha, India.  Correspondence Address :
      Dr. Sarojini Raman,
      Department of Pathology, KIMS, Campus-5, Bhubaneswar-751024, Odisha, India.
      E-mail: sraman10371@gmail.com
       ABSTRACT: Autoimmune bullous lesions are diverse group of diseases characterised by blisters in the skin with or without mucosal lesions. They present with great degree of clinical and histopathological overlap; hence, advanced immunological methods like direct and indirect immunofluorescence techniques have become essential for accurate diagnosis in